joulukuuta 16, 2021 by Philips
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Left main disease

Significant left main CAD (greater than 50%) is found in 3-4% of all patients who undergo coronary angiography.¹

Clinical challenges

Left main angiography is highly uncertain² and can underestimate lesion severity.³

Potential dire consequences of stent thrombosis or restenosis.⁴
Left main disease is associated with multi-vessel CAD about 70% of the time.^5,6

70% reduction in all-cause mortality out to 3 yrs⁵⁷

Advanced tools for optimal PCI outcomes

IVUS Co-registration

Assists in identifying the plaque distribution, vessel size and help avoid geographic miss of therapy delivery with IVUS Co-registration.
Provides better patient outcomes as an IVUS-guided strategy is associated with 70% reduction in all-cause mortality out to 3 years.⁷

Angio Sculpt Evo RX PTCA scoring balloon catheter

AngioSculpt RX PTCA

Provides the power necessary to maximize lume diameter.
Delivers 15-25x’s the focal force of a traditional balloon.^8,9,10

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References

^1. Witzenbichler B et al. Relationship Between Intravascular Ultrasound Guidance and Clinical Outcomes After Drug-Eluting Stents: The ADAPT-DES Study. Circulation 2014 Jan: 129,4;463-470.

^2. Lindstaedt M, et al. How good are experienced interventional cardiologists at predicting the functional significance of intermediate or equivocal left main coronary artery stenoses? Int J Cardiol. 2007;120:254-6.

^3. Arnett, E. N. et al. Coronary artery narrowing in coronary heart disease: comparison of cineangiographic and necropsy findings. Ann. Intern. Med. 91, 350–356 (1979).

^4. Puri R., et al. “Optimizing Outcomes During Left Main Percutaneous Coronary Intervention With Intravascular Ultrasound and Fractional Flow Reserve” JACC Card. Interv. 2012 5(7): 697-707.

^5. Taggart DP, Kaul S, Boden WE, et al. Revascularization for unprotected left main stem coronary artery stenosis stenting or surgery. J Am Coll Cardiol 2008; 51:885.

^6. Serruys PW, Morice MC, Kappetein AP, et al. Percutaneous coronary intervention versus coronary-artery bypass grafting for severe coronary artery disease. N Engl J Med 2009; 360:961.

^7. Park SJ, Kim YH, Park DW, et al. “Impact Of Intravascular Ultrasound Guidance On Long-term Mortality In Stenting For Unprotected Left Main Coronary Artery Stenosis” Circ Cardiovasc Interv. 2009 Jun;2(3):167-77.

^8. AngioSculpt Test Report SR-1571 (2008).

^9. Costa JR, Mintz GS, Carlier SG, et al. Nonrandomized comparison of coronary stenting under intravascular ultrasound guidance of direct stenting without predilation versus conventional predilation with a semi-compliant balloon versus predilation with a new scoring balloon. Am J Cardiol. 2007;100:812-817.

^10. Costa RA, Mooney MR, Teirstein PS, et al. Final results from the multi-center trial of the angiosculpt scoring balloon catheter for the treatment of complex coronary artery lesions Cardiovascular Revascularization Medicine 7 (2006)81–126.